12:00pm – 15:00pm Afternoon Workshop C: The DNA Damage Repair Pathway – Exploring the Various Ways That Inhibiting This Process Can Aid Glioblastoma Treatment
Time: 12:00 pm - 3:00 pm
day: Pre-conference Workshop Day
A challenge that exists across all of pharmacology is passing the BBB. DDR inhibition shows the exciting potential to overcome this issue, so this type of treatment is able to be systemically administered. In addition to this, DDR inhibitors also have the ability to sensitize cells to other therapies like radiotherapy and immunotherapy, enhancing the efficacy of these treatments. Neurooncologists that work with DDRis will unpack the promise of DDRis and evaluate the possibility of a new class of drugs that can be used to treat GBM.
This workshop will cover:
- How effective are DDR inhibitors in penetrating the BBB?
- Maximizing all the benefits of DDR inhibition: looking at combination therapies like radiotherapy
- How DDR inhibitors interact with the microenvironment and how they can be used to enhance immunotherapy?