Developmental Pathways, Plasticity and Neural Regulation of Pediatric High-Grade Glioma

Time: 12:45 pm

Details:

• The architecture of pediatric high-grade gliomas resembles normal
  development
• Histone 3 mutant gliomas (K27M and G34R/V) have distinct developmental origins
• Intra-tumoral hierarchy and plasticity is tumor-type specific
• Targeting lineage specific cancer cell states represents new treatment
  approach