Small molecule epichaperome inhibitors to treat cancers and neurodegenerative disease

Time: 8:10 am

Details:

• Icapamespib (PU-AD) a small molecule epichaperome inhibitor is being
  developed for brain cancers and neurodegenerative diseases
• Icapamespib is BBB permeable, inhibits epichaperome activity,
  initiates degradation of disease associated proteins, normalizes cellular
  pathways and causes cancer cell death or recovery of neuronal functions
• In preclinical studies icapamespib decreased tumor growth in human GBM
  explant xenografts, initiated degradation of oncoproteins and increased survival