Small molecule epichaperome inhibitors to treat cancers and neurodegenerative disease
Time: 8:10 am
day: Day Two
Details:
- Icapamespib (PU-AD) a small molecule epichaperome inhibitor is being
developed for brain cancers and neurodegenerative diseases - Icapamespib is BBB permeable, inhibits epichaperome activity,
initiates degradation of disease associated proteins, normalizes cellular
pathways and causes cancer cell death or recovery of neuronal functions - In preclinical studies icapamespib decreased tumor growth in human GBM
explant xenografts, initiated degradation of oncoproteins and increased survival
