Small molecule epichaperome inhibitors to treat cancers and neurodegenerative disease

Time: 8:10 am


  • Icapamespib (PU-AD) a small molecule epichaperome inhibitor is being
    developed for brain cancers and neurodegenerative diseases
  • Icapamespib is BBB permeable, inhibits epichaperome activity,
    initiates degradation of disease associated proteins, normalizes cellular
    pathways and causes cancer cell death or recovery of neuronal functions
  • In preclinical studies icapamespib decreased tumor growth in human GBM
    explant xenografts, initiated degradation of oncoproteins and increased survival