Conference Day Two

Thursday 16th March 2023

8:30 am Registration & Welcome Coffee

8:55 am Chair’s Opening Remarks

Facing the Funding Dilemma: Investors, Non-Profits & Biotechs Weigh In On the Variety of Funding Avenues for GBM Research

9:00 am Securing Glioma Research Funding Through an Alternative Method: Looking at Chimerix’s Acquistion of Oncoceutics

Synopsis

  • Learning the business development strategy of Chimerix that led to the acquisition of Oncoceutics
  • Understanding the implications of this business strategy for the ONC201 trial
  • Fundraising considerations for randomized glioma drug development

9:15 am Financing the Unfinanceable : An Optimistic Perspective From Europe

Synopsis

  • Let’s learn from history: the temozolomide precedent.
  • Let’s learn from others: the rare diseases examples.
  • Being wise, not too big, not too early : a living dog is better than a dead lion.”

9:30 am Panel Discussion: Navigating the Catch-22 With GBM Funding: How Can Investors & Companies Work Together to Solve This Dilemma?
Moderated by: Scott Rakestraw

Synopsis

  • Unpacking what is holding back pharma from pursuing collaborations in this space
  • Addressing how to attract investment for the indication that the proposition has not yet been clinically proven
  • Discussing gaining support for novel strategies, including combination trials especially when monotherapy has not been proven in isolation
  • Evaluating preclinical models in their reliability to reflect clinical outcomes and which models appeal to investors the most
  • Comparing the two main sources of funding- public vs private funding

10:30 am Morning Networking Break

Synopsis

Meet and connect with your peers in this dedicated networking session.

11:00 am Targeted Oncolytic Viruses Armed With Immune-Modulating Transgene Delivery for Enhanced Activity

Synopsis

  • Understanding the critical components of efficient oncolytic virus entry and spread in GBM cells
  • Unpacking the value of arming purposeful transgenes/payloads to attack the immune suppressive GBM microenvironment

Exciting Opportunities on the Horizon: Exploring Next Wave Therapeutic Modalities

11:30 am PI3K Inhibition With Hypoinsulinaema – A Novel Approach to Maximizing the Impact of Targeted Therapy

  • James Garner Chief Executive Officer, Kazia Therapeutics Limited

Synopsis

  • Reviewing the role of the PI3K pathway in glioblastoma
  • Evaluating the rationale for combining PI3K pathway inhibition with hypoinsulinaemia
  • Overview of an ongoing clinical trial to explore the combination

12:00 pm Delivering On the Promise of Glioblastoma Immunotherapy

  • Natalie Artzi Assistant Professor of Medicine, Harvard Medical School

Synopsis

  • Local delivery in the brain eliminates the need to cross the BBB, opening new
    GBM treatment opportunities
  • Combination therapy that can educate the immune system and generate
    immune memory is required to obtain long-lasting anti-tumor responses
  • Sustained delivery of the therapy is required to bridge the innate and adaptive
    immune responses to obtain immune memory

12:00 pm Laser Interstitial Thermal Therapy: A Novel Technique to Treat Notoriously Hard-to-Reach GBM Tumors

  • John de Groot Division Chief, Neuro- Oncology, UCSF Department of Neurosurgery

Synopsis

  • Discovering the principles of Laser Interstitial Thermal Therapy (LITT)
  • Spotlighting how this approach is useful for patients who are resistant to stereotactic radiosurgery or suffer from radiation necrosis
  • Gaining an insight into a clinician’s perspective of how effective LITT is in practicality

12:15 pm Viral Immunotherapy for Solid Tumors: The New Frontier

  • Paul Peter Tak Chief Executive Officer & President, Candel Therapeutics

Synopsis

  • CAN-2409 treatment is a systemic immunotherapy delivered intra-tumorally, which induces a CD8+ T cell-mediated response against the injected tumor and uninjected distant metastases. It is being tested in the clinic across multiple solid tumors
  • CAN-3110 is a replication-competent HSV gene construct, which is able to replicate specifically in tumor cells while sparing healthy tissue. It is being evaluated in patients with recurrent high-grade glioma
  • The enLIGHTEN™ Discovery Platform makes it possible to design new viral immunotherapies that could synergize with CAR-T cells and other cell therapies

12:45 pm Lunch Break

Synopsis

Take this chance to meet the expert speakers, connect with your peers and explore our exhibition booths.

Spotlighting Nucleic Acid Approaches to Treating GBM- From RNA Vaccines to DNA Drugs

2:00 pm Making Glioblastoma a Target for Immunotherapy: A Road From Biomarker Discovery to Harnessing the Tumor Microenvironment

  • Adilia Hormigo Professor in the Department of Neurology, Medicine (Division of Hematology- Oncology), Mount Sinai Hospital

Synopsis

  • Discussing the use of vaccines for the treatment of glioblastomas
  • Identifying circulating biomarkers, the past and the present
  • Addressing hurdles to overcome to implement the next steps

2:15 pm Targeting OLIG2 in GBM and Medulloblastoma Using CT-179, an Orally Delivered Small Molecule Entering Clinical Development

Synopsis

  • Scientific rationale for targeting OLIG2 in GBM, medulloblastoma, and other
    gliomas
  • Preclinical data supporting the use of CT-179 alone and in combination with
    standard of care therapies
  • Overview of the early-stage clinical development plan for CT-179 in adults with recurrent and newly diagnosed GBM

2:30 pm Uncovering the Use of DNA Medicines for the Treatment of Glioblastoma

  • Jeffrey Skolnik Senior Vice President, Clinical Development, Inovio Pharmaceuticals

Synopsis

  • Explore how DNA as a therapeutic can be employed in the treatment of GBM
  • Discover how combination agents work together to build an immune response against tumor antigens
  • What additional advances can be utilized to continue to optimize clinical outcomes?

The Next Step in GBM Research: Combination Approaches

3:00 pm Afternoon Break

3:30 pm Heavy Atom Nanoparticles for Radiation Enhancement of Glioblastoma

  • Henry Smilowitz Associate Professor, University of Connecticut Health Center

Synopsis

  • Heavy atom nanoparticles (e.g. iodine nanoparticles or INPs) can be used for radiation enhancement
  • The XOFT irradiator can be used to implement INP-RT of resected tumors
  • Combination therapies with INP-RT: Potential for synergy with radiation sensitizers, chemotherapy and immunotherapy

4:00 pm Integrating Pre-Clinical Data & Advanced Radiation Therapy Planning to Maximize the Therapeutic Window For Potent DDRi Radiosensitizers

Synopsis

  • Use of pre-clinical testing to define biologically effective radiosensitizing regimens
  • Use of in vivo radiation toxicity modeling to define potential dose-limiting drug/radiation interactions
  • Use of pre-clinical modeling to select radiation fractionation and modification of clinical planning parameters to maximize the therapeutic window

4:30 pm Chair’s Closing Remarks End of the 4th Annual Glioblastoma Drug Development Summit