Day One

• Reviewing critical lessons from past CAR-T clinical trials in GBM to highlight efficacy barriers caused by the tumor microenvironment
• Detailing next-generation CAR-T strategies designed to resist suppression through the knockdown of upstream receptors that sense TME signals to enhance CAR-T survival in the brain
• Discussing how these novel approaches can overcome GBM’s immune resistant phenotype and achieve durable and efficacious tumour clearance

• Lessons from prior GBM CAR-T trials defining durability requirements and key TME barriers
• Rationale for multiplex editing and validation in patient-derived GBM models
• Why allogeneic CAR-T is well-suited for GBM compared to other modalities

• Discussing the development of a novel cell therapy approach that uses modified macrophages to manipulate the tumor microenvironment in glioblastoma
• Highlighting the translation of a wild-type GBM strategy from the lab into a Phase 1 clinical trial, with a focus on how the therapy’s mechanism impacts patient outcomes
• Exploring the early-stage findings from this study and their implications for the future of GBM therapy, specifically through a patient-centric, immunotherapeutic approach

Put a face to a name – this session is the perfect opportunity to get face-to-face time with key

opinion leaders, leading companies, and innovative researchers in the Glioblastoma field. Establish

meaningful connections and gain individual insight beyond the papers and press releases into the

pioneering research and technique applications.

• Diving into the scientific breakthroughs in GBM immunotherapies including oncolytic viruses, cell therapies and bispecific antibodies to overcome immunosuppression in the brain
• Navigating the biomarker validation process in order to identify reliable and predictive biomarkers accurately assess the effect of immunotherapies for GBM
• Advancing clinical endpoints for immunotherapies to overcome challenges involved with pseudo-progression

• Outlining a strategy for integrating diverse data streams, from molecular biomarkers to advanced imaging, to create a unified view of patient response
• Discussing how real-time insights from biomarkers and imaging can inform dynamic adjustments to drug dosage and treatment schedules, moving beyond traditional safety metrics
• Exploring how this integrated approach can provide a more robust and evidence-based foundation for making critical decisions about advancing the drug to a larger trial

• Discussing strategies for molecular profiling and imaging biomarkers to successfully stratify patients for clinical trials
• Exploring innovative control arms using AI and predictive measure to address budget constraints and patient recruitment challenges
• Overcoming current standard of care involving toxic agents such as TMZ that might hinder the potential benefits of novel therapeutics

• Addressing the lack of analysis of molecular data in current enrolment protocols for GBM trials
• Discussing strategies to incorporate biomarker-based enrolment given the rise of personalized therapies
• Establishing the efficacy of targeted treatments in recurrent GBM to accelerate the delivery of peronalized therapies

• Value of deep genetic characterisation and functional genomics on low-passage patient-derived glioma tumorspheres
• Genetic biomarker identification and validation
• Rapid clinical impact of tumour precision targeting by clinical stage drugs

Our pitch slam welcomes the opportunity for 4 biotechs eager to promote their technology to our

investors through 15-minute presentations with a guaranteed audience of our investment and

pharma business development speakers.

• Identifying specific data packages, preclinical models and clinical milestones that will make a GBM asset attractive for a partnership, beyond scientific novelty
• Strategies for pitching, due diligence considerations and building collaborative relationships to effectively engage with big pharma business development teams to secure a deal
• Insights into creative deal terms, IP considerations and defining clear roles and responsibilities to ensure both partners are aligned on the path to clinical and commercial success

• Tracing the journey of a groundbreaking technology, targeted DNA modification, from its initial discovery at the research bench to its successful translation into a biotech platform
• Detailing the strategic and financial evolution of the technology, highlighting how it attracted investment and ultimately led to a significant acquisition by a major pharmaceutical company
• Examining the path forward for this therapy, exploring how a promising scientific concept, now backed by a major pharma’s resources, is being advanced from the lab to clinical development and ultimately, to the patient’s bedside

• Discussing key milestones, translatable models and biomarkers that are prioritized by investors to mitigate the high-risk nature of GBM drug development
• Exploring how philanthropic funds can de-risk early-stage assets for later VC investment, highlighting overlapping interests and divergencies and how to create a compelling value-proposition for both
• Managing venture philanthropy co-investments, public-private partnerships, and strategic alliances, that are essential for accelerating the development of transformative therapies in this challenging field

Immerse yourself in the most valuable networking session of the conference & discuss your portfolio through face-to-face meetings with our expert panellists.