Advancing Imaging Techniques to Tackle Challenges Associated with Pseudo-progression & Pseudo-response in Glioblastoma Patients
- Join this workshop to discuss best practices and future innovations in brain imaging to distinguish between pseudo-responses and real changes more effectively in GBMs
- Exploring strategies to avoid serial brain biopsies GBM drug development to accurately assess dose selection and discover new biomarkers without invasive techniques
- Discussing advanced neuroimaging strategies to address the challenges of high glucose uptake in the brain such as novel PET ligands that target GBM metabolic pathways beyond glucose
- Evaluating the RANO assessment in modern GBM trials, focussing on how pseudo-progression and pseudo-responses can confound a drug’s true efficacy
- Exploring novel and complementary assessment methods, such as volumetric analysis, advanced imaging biomarkers, and the integration of iRANO criteria for GBM immunotherapies, that can provide a more accurate and reproducible picture of tumor response
- Addressing the practical challenges of standardizing new methodologies across different clinical sites and the regulatory considerations for their use as primary or secondary endpoints