Exploring Next-Generation CAR-T Treatments for Glioblastomas to Overcome the Tumor Microenvironment & Ensure Efficacy

• Reviewing critical lessons from past CAR-T clinical trials in GBM to highlight efficacy barriers caused by the tumor microenvironment
• Detailing next-generation CAR-T strategies designed to resist suppression through the knockdown of upstream receptors that sense TME signals to enhance CAR-T survival in the brain
• Discussing how these novel approaches can overcome GBM’s immune resistant phenotype and achieve durable and efficacious tumour clearance

Speakers:

Ulrike Gerdemann

Assistant professor

Dana-Farber Cancer Institute