Preclinical GBM Research in the Age of FDA Modernization and Predictive Artificial Intelligence
- Selecting human-relevant glioblastoma models through integration of genomic profiling, phenotypic characterization, and clinical alignment to enhance translational accuracy
- Designing orthotopic intracranial studies that maximize translational value through responsible animal use and alignment with evolving FDA guidance under the Modernization Act
- Applying predictive AI/ML to optimize model selection, guide therapeutic strategies, and accelerate biomarker-driven development for GBM therapeutics