Addressing Chemoresistance Using GRP-78 Inhibitors for Reduced Tumor Recurrence
Time: 3:15 pm
day: Conference Day 1
Details:
- Outlining proposed mechanisms for chemoresistance in glioblastoma treatment including how glioblastoma cells under stress express GRP-78 on their surface, leading to the anchoring of proteins like PDL-1 and contributing to chemotherapy resistance
- Discussing the potential of GRP-78 inhibitors in blocking the tumor’s ability to anchor chemotherapy drug efflux pumps and other resistance-related proteins, thereby reducing chemoresistance in GBM
- Investigating how targeting GRP-78 could prevent tumor cells from evading chemotherapy, leading to decreased recurrence rates and improved outcomes in glioblastoma treatment
