Optimizing and Evaluating Glioblastoma Models for Effective Drug Testing
Time: 11:00 am
day: Workshop C
Details:
This workshop will focus on refining and evaluating various models for simulating glioblastoma to enhance drug testing and treatment development. Explore different modelling techniques, assessing their effectiveness in mimicking the GBM microenvironment and translating findings to clinical applications. Cover patient-derived models, genetically engineered mice, and other relevant systems to identify the most suitable approaches for accurate drug screening and therapy optimization.
Key Discussion Points:
- Optimizing Patient-Derived Models: Strategies to refine patient-derived xenograft (PDX) and organoid models for personalized GBM therapies and improved drug screening
- Evaluating Model Utility: Comparing genetically engineered mouse models, xenograft cell lines, and syngeneic models for their relevance to GBM research
- Bridging the Translational Gap: Innovations in 3D and ex vivo culture systems, organ-on-a-chip, and microfluidic platforms to enhance translation from preclinical studies to clinical trials
